A line bundle is a holomorphic complex-dimension-one bundle on a complex manifold.
The complex manifold $X = \mathbb{C}^{\ast} \times \mathbb{C}^{\ast}$ admits a non-trivial line bundle for the following reason: since $X$ is a Stein manifold, Cartan's Theorem B applies. Hence, its Picard group is isomorphic to its second cohomology group with integer coefficients $H^2(X,\mathbb{Z})$. The latter is non-trivial since $X$ has the homotopy of $S^1 \times S^1$.
I would like to see an explicit example of such a line bundle, as I was not able to produce one myself. I tried to write down some bundles arising from divisors, but I don't have a good intuition as to which divisors will give me non-trivial line bundles.