Topological Euler characteristic is given by the top Chern class of the tangent bundle up to sign.
Comments: Examples don't exist in dimension 2 due to Bogomolov–Miyaoka–Yau inequality. Is that true in higher dimensions? Examples are known if one assumes a weaker condition that the holomorphic Euler characteristic is zero.
Wonder after Jason Starr's answer: Is there a minimal manifold of general type with zero Euler characteristic?