The Schwarz--Milnor lemma seems like a good example of what you're asking for. (But, as per my comment, is only really useful in certain contexts, i.e. infinite discrete groups.)
It applies when your "set" $S$ is a proper, geodesic metric space, and your groups $G_i$ are acting properly discontinuously and cocompactly by isometries. (For instance, this will be true of the fundamental groups of two compact metric spaces with isometric universal covers.)
The conclusion is that $G_1$ and $G_2$ are quasi-isometric.
This can enable you to deduce quite a lot of information about $G_1$ from $G_2$. For instance, you can conclude that $G_1$ is finitely generated.
More generally, geometric group theorists have devoted a great deal of effort to proving quasi-isometric rigidity theorems, which then enable you to say something about $G_1$. Famous, and very deep, examples include Gromov's polynomial growth theorem, which handles the case of nilpotent groups, Stallings' ends theorem for free groups, and the convergence group theorem of Casson--Jungreis and Gabai, which handles the case of hyperbolic surface groups.
In the best possible cases, you get to conclude that $G_1$ and $G_2$ are commensurable, meaning that they have isomorphic subgroups of finite index.