Hörmander's definition of a pseudo-differential operator on an open subset $\Omega$
of $\mathbb R^n$ in the class $\text{Op}S^m$ ($m\in \mathbb R$) is the following: take a symbol $a$, that is a smooth function on $\Omega\times\mathbb R^n$ such that
\begin{multline}
\forall K \text{ compact }\subset \Omega, \forall \alpha, \beta\in \mathbb N^n,\ \exists C_{K\alpha\beta},\ \forall (x,\xi)\in K\times\mathbb R^n,\\ \quad
\vert(\partial_x^\alpha\partial_\xi^\beta a)(x,\xi)\vert\le C_{K\alpha\beta} (1+\vert \xi\vert)^{m-\vert \beta\vert},
\tag{1}\end{multline}
and consider the operator $\text{Op}(a)$ defined on $C_c^\infty(\Omega)$ by the formula
$$
(\text{Op}(a) u)(x)=\int e^{2iπ x\cdot \xi} a(x,\xi)\hat u(\xi) d\xi.
$$
Then if you consider a differential operator
$P=\sum_{\vert \gamma\vert\le m} p_\gamma(x) D_x^\gamma
$
with $p_\gamma\in C^\infty(\Omega)$, you find that it is a pseudo-differential operator of order $m$ on $\Omega$ since if $u\in C^\infty_c(\Omega)$, you have
$$
(P u)(x)=\sum_{\vert \gamma\vert\le m}p_\gamma(x)\int e^{2iπ x\cdot \xi}\xi^\gamma \hat u(\xi) d\xi
=\int e^{2iπ x\cdot \xi}p(x,\xi) \hat u(\xi) d\xi,
$$
with $p(x,\xi)=\sum_{\vert \gamma\vert\le m}p_\gamma(x)\xi^\gamma$; the symbol $p$ obviously verifies (1).