There is an obvious (?) notion of cofibration in a category of fibrant objects, namely a morphism which satisfies the left lifting property with respect to all trivial fibrations. I don't seem to be able to find a place in the literature where this concept is discussed.
For a concrete question: suppose $A$ is a cofibrant object in a category of fibrant objects $\mathcal{C}$, and $X_\bullet\to X$ is a simplicial resolution of the object $X$ of $\mathcal{C}$. Does the simplicial set $X_\bullet(A)$ represent the homotopy type of the mapping space $\mathop{Hom}(A,X)$ in the simplicial localization of $\mathcal{C}$?