Let $M$ be a model topos and $S$ a set of morphisms, there exists a set of morphism $\bar{S}$ which is generated by the $S$-local equivalences which is closed under homotopy pullbacks in $M$. Suppose that $M$ is left proper combinatorial, then the Bousfield localisation $M_{\bar{S}}$ is a model topos [Prop.6.2.1.2, HTT, Lurie].
Let $sPre(C)$ be the category of simplicial presheaves of an essentially small category $C$, the fibrant objects of the Bousfield localisation with respect to the set of all hypercovers $S$ are precisely the $S$-local objects, that is, the presheaves of Kan complexes satisfying descent for all hypercovers. Under suitable condition, this localisation is equivalent to the localisation of the set of all bounded hypercovers. And a presheaf satisfies descent for all bounded hypercover is equivalent to that it satisfies Čech descent. Thus the fibrancy condition can be reformulated for Čech descent which is a relatively concrete condition.
In the case of Nisnevich descent, where $C$ is a site whose topology is defined by a complete bounded regular cd structure, the fibrancy condition can be stated for the distinguished square, that is, a simplicial presheaf $F$ is fibrant if and only if $F$ takes values in Kan complexes and it takes every elementary ditinguished square to a homotopy pullback.
Let $\alpha$ be a Nisnevich distinguished square, $\require{AMScd}$ \begin{CD} W @>>> Y \\ @VVV @VpVV\\ U @>i>> X \end{CD} and let $P(\alpha)\to X$ be the morphism from the pushout of the upper part $U\leftarrow W \rightarrow Y$ to $X$.
Question: Consider the set of morphism $Nis=\{P(\alpha)\to X\}_{\alpha}$ and the localisation $sPre(C)_{\overline{Nis}}$ of $\overline{Nis}$, are the fibrant objects of $sPre(C)_{\overline{Nis}}$ the same as $sPre(C)_{{Nis}}$?
Further question after edit: Consider the category $sPre(C)_{\mathbb{A}_1,\overline{Nis}}$ which has a different model category structure than the motivic homotopy category $sPre(C)_{\mathbb{A}_1,{Nis}}$, are the fibrant objects in $sPre(C)_{\mathbb{A}_1,\overline{Nis}}$ the same as that for $sPre(C)_{\mathbb{A}_1,{Nis}}$?
I slightly modified the question as now the question is not generally about hypercover as I thought. What I'm looking for are the fibrant objects in the model topos $sPre(C)_{\mathbb{A}_1,\overline{Nis}}$. In the comments below, Pavlov mentioned the paper by Strunk and Raptis,
Let $\mathcal{C}$ be a small simplicial category. Then there is a bijective correspondence between Grothendieck topology $\bar{\tau}$ on $Ho(\mathcal{C})$ and homotopy left exact left Bousfield localization of $sPSh^{\Delta}(\mathcal{C})$ which are $t$-complete.
where a $\mathcal{U}$-local model topos $sPSh^{\Delta}(Sm_S)_{\mathcal{U}Nis}$ is given together with its Grothendieck topology arising from Nisnevich topology on the ordinary category $Sm_S$. $sPSh^{\Delta}(\mathcal{C})$ denotes the functor category of simplicial functors $\mathcal{C}^{op}\to \mathcal{sSet}$ for a small simplicial category $\mathcal{C}$. A Grothendieck topology for a simplicial category $\mathcal{C}$ is by definition a Grothendieck topology on $Ho(\mathcal{C})$.
Given a Grothendieck topology above, the model structure of the localization can be described by hypercovers of this topology. By this theorem, there should be a Grothendieck topology for $Ho(Sm_k)$ that gives the localisation $(sPSh^{\Delta}(Sm_S)_{\mathcal{U}Nis})_{\overline{\mathcal{H}(Nis)}}\cong sPsh(Sm_k)_{\mathcal{A_1},\overline{Nis}}$ of $sPsh^{\Delta}(Sm_k)$. The Grothendieck topology of the $\mathcal{U}$-local model topos $sPSh^{\Delta}(Sm_S)_{\mathcal{U}Nis}$ arises from the Nisnevich topology of $Sm_k$ as ordinary category. So this topology isn't the one that gives the final localization.
How can one determine this Grothendieck topology hence find the fibrant objects of $sPre(C)_{\mathbb{A}_1,\overline{Nis}}$?
