Suppose $R$ is an integral domain with quotient field $K$ and $f \in R[x]$ is an irreducible polynomial.
Under what conditions on $R$ and $f$ can we conclude that $f$ is irreducible in $K[x]$?
It is well-known that if $R$ is factorial, then this holds for any polynomial. It is perhaps a bit less well-known that factorial can be weakened to GCD domain.
Obviously, if $R$ is integrally closed, then this will hold for any monic polynomial.
Are there any other results of the same type?