You are probably thinking about the following type of phenomenon:
Example. Let $X = \mathbb A_k^1$, and consider the ringed site $((\operatorname{\underline{Sch}}/X)_{\text{fppf}},\mathcal O)$, where $\mathcal O$ means the sheaf whose value on $T \in \operatorname{\underline{Sch}}/X$ is $\Gamma(T,\mathcal O_T)$. The pullback functor
$$\operatorname{\underline{Qcoh}}(\mathcal O_X) \to \operatorname{\underline{Qcoh}}((\operatorname{\underline{Sch}}/X)_{\text{fppf}},\mathcal O)$$
is an equivalence of categories by a standard descent argument [Tag 03DX]. Thus, as you already indicated by your notation, $\operatorname{\underline{Qcoh}}(X)$ does not depend on the site in this case.
However, if we take an injection of quasi-coherent $\mathcal O_X$-modules like $\mathcal O_X \stackrel{x}\to \mathcal O_X$ and pull back along the morphism $\operatorname{Spec} k = \{0\} \to \mathbb A^1_k$, we get the map $k \stackrel 0 \to k$. This is not injective.
Since injectivity of a morphism of sheaves $\mathscr F \to \mathscr G$ on a ringed site $\mathscr C$ means that for every $U \in \mathscr C$ the map $\mathscr F(U) \to \mathscr G(U)$ is injective, we see that the map $\mathcal O_X \stackrel x \to \mathcal O_X$ is not injective as a map of $\mathcal O$-modules on $(\operatorname{\underline{Sch}}/X)_{\text{fppf}}$.