Yes, but it must have uncountable cofinality. So if it is to be singular, the smallest possibility is $\aleph_{\omega_1}$.

The basic fact is that if $\kappa$ is any cardinal such that $\kappa^\omega=\kappa$, then there is a forcing extension $V[G]$ in which $2^\omega=\kappa$. The forcing to achieve this is $\text{Add}(\omega,\kappa)$, which consists of finite partial functions from $\kappa\times\omega$ to $2$.

In particular, if you start with GCH in the ground model, and add $\aleph_{\omega_1}$ many Cohen reals, then you will have $2^\omega=\aleph_{\omega_1}$ in the forcing extension. The proof uses the following facts: (1) adding any number of Cohen reals is c.c.c. and therefore preserves all cardinals. (2) The forcing clearly adds at least that many reals. (3) A nice name argument shows that every real in the extension has a nice name in the ground model, and there are only $\aleph_{\omega_1}$ many such names. So the continuum of the extension is exactly $\aleph_{\omega_1}$. The same ideas work for any $\kappa$ for which $\kappa^\omega=\kappa$.