This answer relates mainly to the term "Higher refinement of Seifert-van Kampen Theorem", rather than homotopy colimit.
Last week I gave a talk to the 2015 Category Theory Meeting in Aveiro, entitled "A philosophy of modelling and computing homotopy types". The Abstract and full and handout versions (slightly refined) are available on my preprint page. Homotopy colimits enter from the side in order to get a "nice" pushout of spaces, but the aim is
explicit nonabelian pushout computations of certain **homotopy types.
It is often hard work to compute from this homotopy groups and $k$-invariants! (There was also no time for indications in the talk.)
I do not know of an account of a homotopy theory, and so of "homotopy colimits", for the crossed squares used in this presentation for modelling, and some computations of, homotopy $3$-types.
Later: I'll add that in 1965 I found the nice statement and proof for the fundamental groupoid $\pi_1(X)$ of a space which was a union of open sets. I thought: great! One can get rid of base points!
Then I found this was not enough for my first aim, getting as a Corollary the fundamental group of the circle. So then I discovered the applications of the fundamental groupoid $\pi_1(X,A)$ on a set $A$ of base points, chosen according to the geometry of the given situation. In particular, the determination of the fundamental group of the circle required at least $2$ base points. These results were published in 1967.
This simple extension of the theorem and proof of the usual van Kampen theorem is, to my knowledge, given in topology texts in English only in the 1968, 1988, 2006 editions of what is now titled "Topology and Groupoids".
As for higher versions of the nonabelian fundamental group, these were sought by the topologists of the early 20th century topologists (Dehn, Cech, Hopf, ...) but I think did require for the proof a shift from groups to groupoids, and a 2-dim Seifert-van Kampen Theorem was published by Philip Higgins and I in 1978. That was a theorem on second relative homotopy groups.
June 24: The updated Abstract of the Aveiro presentation is as follows, and I hope shows some special features of this approach to Higher Seifert-van Kampen Theorems:
ABSTRACT
This philosophy involves functors $\mathbb H$ from (Topological Data) to (Algebraic Data), and conversely "classifying space" functors $ \mathbb B$ from (Algebraic Data) to (Topological Data). These should satisfy:
- $\mathbb H$ is homotopically defined.
- $\mathbb{ HB}$ is naturally equivalent to 1.
- The Topological Data has a notion of connected.
- For all Algebraic Data $A$, we have $\mathbb BA$ is connected.
- $\mathbb H$ preserves certain colimits of connected Topological Data.
The Algebraic Data splits into several equivalent kinds, ranging from "broad" to "narrow", related by Dold-Kan type equivalences. The broad data is used for conjecturing and proving theorems; the narrow data is used for calculations and relating to classical methods.
As examples of Algebraic Data we give groupoids, crossed modules and crossed squares. We give a sample computation, using crossed squares, of the homotopy 3-type of the mapping cone of the classifying space of a morphism of crossed modules.