In Chung and Graham's "Erdős on Graphs: His legacy of unsolved problems," they discuss several open problems concerning Turán numbers for bipartite graphs.
There is a construction which gives graphs on $n$ vertices with $C n^{5/3}$ edges, with no $K_{3,3}$ subgraphs, and at the time of the writing of this book there was no better lower bounds on the Turán number of $K_{4,4}$.
Is it known whether $$\lim_{n\to \infty} \frac{ \mbox{ex}\left(n ; K_{4,4}\right) }{n^{5/3}} = \infty ? $$
(Here $\mbox{ex}(n ; H)$ is the maximum number of edges for an $n$-vertex graph with no subgraphs isomorphic to $H$.)