Consider an abelian category $\mathcal{A}$ (or more specifically, $R$-Mod). Suppose $C_1$ and $C_2$ are chain complexes with componentwise isomorphic homology. What conditions must be imposed upon $\mathcal{A}$ (or $R$), or $C_1$ and $C_2$, for there to exist a quasi-isomorphism $\alpha: C_1 \to C_2$? Or, under what conditions, if any, is there necessarily an isomorphism $C_1 \cong C_2$ in $\mathcal{D}(\mathcal{A})$?
I certainly expect existing conditions to be rare. If the answer is "there basically are none" then I'd like to see some good examples highlighting this too!