Classically, the (non-local-coefficients) homology Whitehead theorem says that if $X \xrightarrow f Y$ is a map of simple spaces, and if the induced map $H_\ast(X;\mathbb Z) \to H_\ast(Y;\mathbb Z)$ is an isomorphism, then $f$ is a weak homotopy equivalence.
Conceptually for me, the essence of this theorem is that we have a stable invariant ($H_\ast(-;\mathbb Z)$), and we identify a (reasonably large) class of spaces (the simple spaces) such that our invariant detects equivalences when restricted to this class. I'm wondering how generally a statement of this form holds in a fairly general $\infty$-category $\mathcal C$ in place of $Spaces$.
For my purposes, I'm not particularly concerned with which stable invariant we use, so we might as well restrict attention to the universal case. Moreover, there are two general forms of "stabilization" which come to mind -- the category of spectrum objects $Sp(\mathcal C) = \varprojlim (\cdots \xrightarrow \Omega \mathcal C_\ast \xrightarrow \Omega \mathcal C_\ast)$, and the Spanier-Whitehead category $SW(\mathcal C) = \varinjlim (\mathcal C_\ast \xrightarrow \Sigma \mathcal C_\ast \xrightarrow \Sigma \cdots)$ (I use $\mathcal C_\ast$ to denote the $\infty$-category of pointed objects in $\mathcal C$). But we're eventually passing to some subcategory anyway, so we can reduce the $SW$ notion to the $Sp$ notion if we start out by replacing $\mathcal C$ with $Ind(\mathcal C)$ via the equation $Ind(SW(\mathcal C)) = Sp(Ind(\mathcal C))$.
Thus we are led to the following formulation:
Question: Let $\mathcal C$ be a presentable $\infty$-category. Can we identify a (reasonably large) full subcategory $\mathcal D \subseteq \mathcal C$ such that the composite functor $\mathcal D \to \mathcal C \xrightarrow {\Sigma^\infty_+} Sp(\mathcal C)$ is conservative? In particular, is this the case for $\mathcal D$ being one of the following?
The 1-fold suspension objects?
The 1-fold loop objects?
The 1-connected objects?
Here, a 1-fold suspension object is simply an object of the form $X = \Sigma Y$ for some $Y \in \mathcal C$; a 1-fold loop object is an object of the form $X = \Omega Y$ where $Y \in \mathcal C_\ast$ is a pointed object of $\mathcal C$. A 1-truncated morphism $W \to Z$ is a morphism such that for every $C \in \mathcal C$, the map $\mathcal C(C,W) \to \mathcal C(C,Z)$ has 1-truncated fibers, a morphism is 1-connected if it is left orthgonal to the 1-truncated morphisms, and an object $X$ is 1-connected if the map $X \to 1$ is 1-connected, where $1$ is the terminal object.
As a sanity check, I think each of my candidates for $\mathcal D$ are trivial when $\mathcal C$ has discrete hom-spaces, which is a good thing because in this case $Sp(\mathcal C)$ is also trivial.