The Atiyah-Singer theorem is a major achievement of twentieth century mathematics. It has inspired a lot of work and people started to develop generalizations of this theorem. I would like to know the current state of the theory and current central problems in index theory. Let me mention some possible generalisations:
More than one operator This approach was initiated by Atiyah himself in the index theorem for families of operators. Possible generalizations are index theorems for foliations (for easy foliations which are fibrations it implies the index theorem for families).
Higher index theory This line of research concerns manifolds which are $G$-spaces and equivariant operators or more generally, noncompact (complete, Riemannian) manifolds (as in the work of John Roe). The prominent examples are universal covers of non-simply connected manifolds (where the fundamental groups acts).
Non-smooth manifolds Examples include combinatorial manifolds, Lipschitz manifolds and quasiconformal manifolds. This direction was developed mostly by Nicolae Teleman.
Non-commutative geometry This whole discipline is heavily inspired by index theory: in fact the points mentioned above use the machinery of noncommutative geometry. There is an abstract local index theorem for spectral triples of Connes-Moscovici.
What are most important current directions and trends in index theory? What are the most important problems in index theory?