Let $G$ be a simply connected group over an algebraically closed field $k$, and
$I:=\{(g,\gamma)\in G\times G\vert~ g\gamma=\gamma g\}$
the scheme of centralizer.
Is $I$ a Cohen-Macaulay scheme over $k$?
The answer is not known. In fact, the analogous result for the "commuting variety" $\mathcal{C}(\mathfrak{g})$ of a reductive Lie algebra $\mathfrak{g}$ ($\mathcal{C}(\mathfrak{g})=\{(x,y)\in \mathfrak{g}\times \mathfrak{g}\ |\ [x,y]=0\}$) is a classical conjecture -- even the normality of $\mathcal{C}(\mathfrak{g})$ is not known. See V. Popov, Irregular and singular loci of commuting varieties. Transform. Groups 13 (2008), no. 3-4, 819–837 (MR).