The question's in the title and is easily stated, but let me try to give some details and explain why I'm interested. First, a disclaimer: if the answer's not already somewhere in the literature then it could be rather hard; I'm asking this question here because MO is lucklucky enough to have some of the foremost experts on lacunary hyperbolic groups as active participants.
Note: This paper of Denis Osin already makes a connection between equations over a single lacunary hyperbolic group and equations over the class of all hyperbolic groups.
This question attracted great answers from Yves Cornulier and Mark Sapir, as well as some excellent comments from Denis Osin. Let me quickly clarify my goals in answering the question, and try to summarise what the state of knowledge seems to be. I hope someone will correct me if I make any unwarranted conjectures!
My motivation came from the theory of equations over the class of all (word-)hyperbolic groups. For these purposes, it is not important to actually find a non-Hopfian lacunary hyperbolic group; merely a non-Hopfian limit of hyperbolic groups is enough. (That is, the injectivity radius condition in the above proposition can be ignored.) Yves Cornulier gave an example of a limit of virtually free (in particular, hyperbolic) groups which is non-Hopfian. From this one can conclude that the class of word-hyperbolic groups is not equationally Noetherian, as I had hoped.
[Note: I chose to accept Yves's answer. Mark's answer is equally worthy of acceptance.]
Clearly, the pathologies of Yves's groups derive from torsion---the class of free groups is equationally Noetherian---and there are some reasons to expect torsion to cause problems, so I asked in a comment for torsion-free examples. These were provided by Denis Osin, who referred to a paper of Ivanov and Storozhev. Thus, we also have that the class of all torsion-free hyperbolic groups is not equationally Noetherian.
Let us now turn to the question in the title---what if we require an actual lacunary hyperbolic group that is non-Hopfian. First, it seems very likely that such a thing exists. As Mark says, 'A short answer is "why not?"'. More formally, Denis claims in a comment that the subspace of the space of marked groups consisting of lacunary hyperbolic groups is comeagre in the closure of the subspace of hyperbolic groups. This formalises the idea that lacunary hyperbolic groups are not particularly special among limits of hyperbolic groups.
Mark also suggested two possible approaches to constructing a non-Hopfian lacunary hyperbolic group; however, in a comment, Denis questioned whether one of these approaches works. In summary, I feel fairly confident in concluding that a construction of a non-Hopfian lacunary hyperbolic group is not currently known, although one should expect to be able to find one with a bit of work.