First here, by the Cauchy--Schwarz inequality, $$E|z_1z^*_2|=E|z_1|\,|z^*_2|\le\sqrt{E|z_1|^2E|z^*_2|^2}=E|z_1|^2<\infty,$$ by Addition in response to the modification of the OP's original question. So, $Ez_1z^*_2$ exists and is finite. Therefore and because the joint distribution of the pair $(-z_1,z^*_2)$ is the same as that of $(z_1,z^*_2)$, we conclude that $$Ez_1z^*_2=E(-z_1)z^*_2=0.$$
Detail sdded in response to the OP's comment: The $x_i$'s are iid and, for each $i$, the distribution of $-x_i$ is the same as that of $x_i$. So, the joint distribution of $(-x_1,x_2,\dots,x_M)$ is the same as that of $(x_1,x_2,\dots,x_M)$. Also, $|-x_1|=|x_1|$. So, the random pair \begin{multline*} (z_1,z^*_2)=g(x_1,x_2,\dots,x_M):= \\ \Big(\frac{x_{1}}{|x_{1}|^2 + |x_{2}|^2 + \dots + |x_{M}|^2}, \frac{x_{2}}{|x_{1}|^2 + |x_{2}|^2 + \dots + |x_{M}|^2}\Big) \end{multline*} equals \begin{multline*} (-z_1,z^*_2)=g(-x_1,x_2,\dots,x_M)= \\ \Big(\frac{-x_{1}}{|-x_{1}|^2 + |x_{2}|^2 + \dots + |x_{M}|^2}, \frac{x_{2}}{|x_{1}|^2 + |x_{2}|^2 + \dots + |x_{M}|^2}\Big) \end{multline*}\begin{multline*} (-z_1,z^*_2)= \Big(\frac{-x_{1}}{|-x_{1}|^2 + |x_{2}|^2 + \dots + |x_{M}|^2}, \frac{x_{2}}{|x_{1}|^2 + |x_{2}|^2 + \dots + |x_{M}|^2}\Big) \\ =g(-x_1,x_2,\dots,x_M) \end{multline*} in distribution, as was stated above.