We still have no fundamental formulation of “M-theory” - the hypothetical theory of which 11-dimensional supergravity and the five string theories are all special limiting cases. Work on formulating the fundamental principles underlying M-theory has noticeably waned. [...]. If history is a good guide, then we should expect that anything as profound and far-reaching as a fully satisfactory formulation of M-theory is surely going to lead to new and novel mathematics. Regrettably, it is a problem the community seems to have put aside - temporarily.
But, ultimately, Physical Mathematics must return to this grand issue.
(G. Moore, "Physical Mathematics and the Future", talk at Strings 2014)