It's a result of low-dimensional topology that in dimensions 3 and lower, two manifolds are homeomorphic if and only if they are diffeomorphic. The 28 differentiable structures on Milnor's 7-spherespheres give a nice counterexamplecounterexamples to this result in dimension 7, and exotic $\mathbb{R}^4$ gives a's give nice counterexamplecounterexamples in dimension 4. But I don't know about dimensions 5 and 6. Is the result true or false in dimensions 5 and 6? And, and if false, what are some classic counterexamples, and do stronger constraints -- say compactness or closedness -- happen to make it true?