Consider the set $S=\{1,2,\ldots, n\}$, and let $a<b<n$. What is the minimum number $f(a,b)$ such that there exist $f(a,b)$ subsets of $S$ of size $a$ for which any subset of $S$ of size $b$ contains at least one of the chosen subsets?
It is not hard to obtain a bound $f(a,b)\leq \dbinom{n}{a}-\dbinom{b}{a}+1$, as is shown herehere. But it doesn't seem easy to go beyond that. However, since this is such a simply-stated question, I would expect that it has been well-studied in combinatorial set theory. So, any references to better upper or lower bounds (or better yet, the exact answer) would be appreciated.