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When first learning about universal covers and Galois correspondence of topological spaces, I remember feeling that conditions like "path-connected and semi-locally simply connected" were rather subtle.
@HarryGindi I got a sense that something like this was the case, from the first reference, but I'm not used to thinking about lattices and partial orders, so I didn't gain much from this. I know a la here this captures most of Zariski topology, but somehow that doesn't console me.
Thanks. Still need to think a bit more about your remarks, but it's helpful. It doesn't change your conclusion, but wouldn't $S_{\{p\}}$ invert $p$ and the numbers congruent to $1$ mod $p$? I also suspected they were commutative, but couldn't prove, and had reservations relating to regular sequences (I'm editing to add).