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I took a look at the Fillmore paper, and just before his Corollary to Theorem 2 -- which reads "Corollary. There exists an analytic hypersurface of constant width in E^n having the same group of symmetries as a regular n-simplex." -- he writes "If we imitate the construction of a Reuleux triangle . . .. Thus:" This seems to imply that he is assuming that [the intersection of four balls in 3-space, centered at the vertices of a regular tetrahedron and each with radius = the side-length of the tetrahedron] is a body of constant width. But this is known to be false.
The usual contractible 2-complex discovered by Bing is called a "House With Two Rooms", and this is not what is depicted in the image above this answer. The 2-complex depicted is not contractible (since a loop around either inner cylinder is a nontrivial 1-cycle, as is easily verified). To obtain the House With Two Rooms, one needs to add two disjoint rectangles IxI to the image, each one intersecting one inner cylinder in an interval, the outer cylinder in an interval, and the 2-complex depicted in its entire (rectangular) boundary circle.
Removing a standard $D^4$ from a potentially-exotic smooth $S^4$ yields a potentially-exotic $\mathbb{R}^4$ that's standard at infinity. So if it were known that the latter must be globally standard, then replacing the $D^4$ would imply the original $S^4$ is standard, and hence the 4-dimensional smooth Poincaré conjecture. And there's essentially only one way to replace the $D^4$, since Gamma_4 = 0 (Cerf) implies oriented diffeos of $S^3$ are smoothly isotopic.
For one application, an explicit curve {C(t) : t in [0,oo)}, dense in a Grassmannian of 2-planes in n-space, is the basis for the animation technique in statistical computer graphics known as the Grand Tour. It's important to ensure that as t -> oo, the curve C spends time in any open set U proportional to the invariant measure* of U. * Though the invariant measure on a Grassmannian is unique up to a scalar multiple, the invariant metric is not in the sole case of 2-planes in 4-space. This oriented Grassmannian's metric is the product of two round 2-spheres whose radii may be in any ratio.