I have been working recently on a problem that appears to be related, namely, maximizing the absolute value of the determinant of a chosen $m\times m$ submatrix $S$ of a $m\times N$ submatrix $V$ (think to the columns of $V$ as your vectors). I can tell you the following. * Finding the maximum volume submatrix is an [NP-hard problem][1], so I guess that your problem may suffer the same fate * a useful relaxation, however, is finding a submatrix that has *locally* maximum volume, i.e., larger than all those that can be obtained by changing one vector only. There is a [paper][2] by Knuth (yes, *that* Knuth) that studies the problem. The interesting feature is that in this way the matrix $S^{-1}V$ has a submatrix equal to the identity matrix (obvious) and *all other entries bounded in modulus by 1*. This is enough to ensure good conditioning, at least in the applications that we were [investigating][3]. One can prove that the rows of the matrix $V$ are a well-conditioned basis for its row space, for instance. Another reference is [this paper][4]. * a second relaxation is finding a submatrix $S$ such that $S^{-1}V$ has all entries bounded by some real $\tau>1$. This problem can be solved explicitly in $O(Nm^2\frac{\log m}{\log\tau})$. The good conditioning properties carry over to this relaxation, up to a factor $\tau$. Putting everything together, I think that one can prove using the techniques in our paper that the matrix chosen by the algorithm has conditioning within $O(\sqrt{Nm}\tau)$ from the conditioning of the rectangular matrix $V$ (defined as largest over smallest singular value), which is a theoretical maximum for the conditioning of $S$ (I think). * if you have a practical computation and you want to check how things work with this solution, I have some [Matlab code][5] in a packaged and usable state that you might wish to try out. Feel free to ask for explanation if the documentation is too poor. [1]: http://dx.doi.org/10.1007/s00453-011-9582-6 [2]: http://dx.doi.org/10.1080/03081088508817636 [3]: http://opus4.kobv.de/opus4-matheon/frontdoor/index/index/docId/906 [4]: http://spring.inm.ras.ru/osel/?p=13 [5]: https://bitbucket.org/fph/pgdoubling/overview