If $G$ is an adjoint algebraic group then it is always simple as an abstract group, (EDIT: This is because any proper normal subgroup of a simple algebraic group must be finite and lie in the centre). In general assume $G$ is connected reductive algebraic group and let $\pi : G \to G_{ad}$ be an adjoint quotient of $G$. Then $G$ is simple as an abstract group if the kernel of $\pi$ is trivial because $\pi$ is then an isomorphism of abstract groups. If $\pi$ does not have a trivial kernel then it is clear that $G$ is not simple as an abstract group.

For an example: in characteristic 2 the symplectic group $Sp_{2n}$ is simple as an abstract group as it is isomorphic (as an abstract group) to the corresponding adjoint group. However these two groups are not isomorphic as algebraic group (only isogenous).