$\newcommand\R{\mathbb R}$The answer is no. 

Let us use the terms "acute angle" and "positive" in the nonstrict sense, meaning "angle $\le\pi/2$" and $\ge0$, respectively. The "strict" modification should be straightforward. By approximation, we may also assume that the set of vectors is allowed to be infinite. 

Now, for any vector $u$ in $\R^d$ ($d\ge3$) with Euclidean norm $|u|=1$, consider the set  
$$S_u:=\{u+v\colon\, v\in\R^d,|v|=1,v\cdot u=0\},$$ 
with $\cdot$ denoting the dot product. (One may note that $S_u$ is the unit-radius circle in $\R^d$ centered at $u$ and lying in the affine plane through $u$ perpendicular to $u$.) Then for any vector $u+v\in S_u$ the angle between $u+v$ and $u$ is $\pi/4$ and hence, by the subadditivity of the angle measure, the angle between any two vectors in $S_u$ is acute. 

Moreover, any rotation of $S_u$ is of the same form, $S_u$, but maybe for another unit vector $u$. 

It remains to show that $S_u\not\subseteq\R_+^d$ for any unit vector $u$. Take indeed any such vector $u=(u_1,\dots,u_d)$. Without loss of generality, $u_1$ is the smallest of all the $u_j$'s, so that 
$$u_1-\sqrt{1-u_1^2}<0.$$
Let now 
$$v=(v_1,\dots,v_d):=\Big(-\sqrt{1-u_1^2},\frac{u_1u_2}{\sqrt{1-u_1^2}},\dots,\frac{u_1u_d}{\sqrt{1-u_1^2}}\Big).$$
Then $u+v\in S_u$. However, $u_1+v_1<0$, so that $S_u\not\subseteq\R_+^d$. $\quad\Box$

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The picture below shows the set $[0,1]S_u=\{tw\,\colon t\in[0,1],w\in S_u\}$ for $d=3$ and (the apparently "best") unit vector $u=\frac1{\sqrt3}\,(1,1,1)$. It is kind of seen that $[0,1]S_u\not\subseteq\R_+^d$ and hence $S_u\not\subseteq\R_+^d$. 

[![enter image description here][1]][1]


  [1]: https://i.sstatic.net/27X05.png