I'm not sure if the questions make sense: 
Conc. primes as knots and Spec Z as 3-manifold - fits that to the Poincare conjecture? Topologists view 3-manifolds as Kirby-equivalence classes of framed links. How would that be with Spec Z? Then, topologists have things like virtual 3-manifolds, has that analogies in arithmetics?

An other such question:
Minhyong Kim <a href="http://londonnumbertheory.wordpress.com/2009/11/04/optimal-proofs/" title="London NT seminar blog">stresses</a>
the special complexity of number theory: "To our present day understanding, number fields display exactly the kind of order ‘at the edge of chaos’ that arithmeticians find so tantalizing, and which might have repulsed Grothendieck." Probably a feeling of such a special complexity makes one initially interested in NT. Knot theory is an other case inducing a similar impression. Could both cases be connected by the analogy above? How could a precise description of such special complexity look like and would it cover both cases?