As noticed by Sasha in his comment, the answer is no. Let me give some more details on the proof.

Given a smooth complex hypersurface of degree d, say $X_d \subset \mathbb{P}^{n+1}$, by standard arguments involving Lefschetz theorem we have 

$H^k(X_d)= H^k(\mathbb{P}^n)$  for $k \neq n$.

In particular, all the odd Betti numbers are zero, except possibly the middle Betti number 
when $n$ is odd. On the other hand, the Euler-Poincare characteristic of $X_d$ can be computed and it is equal to

$\chi(X_d)=\frac{1}{d}[(1-d)^{n+2}-1]+n+2$,

so for $d=2$ and  $n$ odd the middle cohomology group must be zero too.  

A good reference on these topics is Dimca's book "Singularity and topology of hypersurfaces".