Buzzard is correct to be skeptical of the most naive arguments: Erdos observed that $2^n + 9262111$ is never prime.

[**edit** Jan 2017 by Buzzard: the 9262111 has sat here for 7 years but there's a slip in Pomerance's slides where he calculates the CRT solution. The correct conclusion from Pomerance's arguments is that $2^n+1518781$ is never prime. Thanks to Robert Israel for pointing out that $2^{104}+9262111$ is prime.]

Question one is an incredibly classical problem, of course. Observe that the proof that $2^n + 3$ and $2^n + 5$ are both prime finitely often can plausibly work for a single expression $2^n + c$ for certain $c$. It suffices to find a finite set of pairs $(a,p)$ where $p$ are distinct primes such that every integer is congruent to $a$ modulo $p - 1$ for at least one pair $(a,p)$. Then take $-c$ to be congruent to $2^{a}$ modulo $p$. (Key phrase: covering congruences).
I could write some more, but I can't really do any better than the following very nice elementary talk by Carl Pomerance:

www.math.dartmouth.edu/~carlp/PDF/covertalkunder.pdf 

Apparently the collective number theory brain of mathoverflow is remaking 150 year old conjectures that have been known to be false for over 50 years! I was going to let this post consist of the first line, but I guess I'm feeling generous today. On the other hand, I'm increasingly doubtful that I'm going to get an answer to [question 2339](http://mathoverflow.net/questions/2339/).