Conway's [Thrackle Conjecture][1]: $E \le V$ in any "thrackle," a particular type of drawing of a graph of $V$ vertices and $E$ edges in the plane. Dangerously addictive! And advances made every few years; it is by no means an isolated conjecture. <br /> ![Thrackle][2] [1]: http://en.wikipedia.org/wiki/Conway%27s_thrackle_conjecture [2]: http://upload.wikimedia.org/wikipedia/en/thumb/4/44/6-cycle_thrackle.png/220px-6-cycle_thrackle.png