I’ll write the weight of $S^\vee$ as $(0,\ldots,0,-1)$; it might be helpful to think of this bundle as $\bigwedge^{k-1}S \otimes \det(S)^{-1}$. For $\mathrm{Sym}^2(S)$ the weight is $(2,0,\ldots,0)$; both of these are vectors with $k$ entries. By the Pieri rule, $$S^\vee \otimes \mathrm{Sym}^2(S) \cong S \oplus \mathbb{S}_{(2,0,\ldots,0,-1)}(S),$$ where $\mathbb{S}$ denotes the Schur functor. Similarly the weight of $Q^\vee$ is $(0,\ldots,0,-1)$ (with $n-k$ entries). So we concatenate the weights for each of the two summands: $$w = (0,\ldots,0,-1,1,0,\ldots,0) \text{ and } w'= (0,\ldots,0,-1,2,0,\ldots, 0,-1).$$ By Borel-Weil-Bott we add $\rho = (n,n-1,\ldots,1)$ and count inversions in the resulting word; if there is a repeat, all the cohomology vanishes. In the first case there is exactly one inversion, so the bundle has nonvanishing $H^1$. After sorting, the resulting weight is $$\mathrm{sort}(w+\rho)-\rho = \vec{0}$$ So $H^1$ is one-dimensional (the trivial representation). For the other, $w'+\rho$ has a repeat from the $2$ and the $0$ two steps before it. So all the cohomology vanishes.