I am trying to understand the Atiyah-Singer index formula for pseudo-differential operators. As far as I understood the Fredholm index of the operator $A$ on a manifold can be computed just from the knowledge of its associated principal symbol $\sigma_p(A)$, at least for elliptic operators. However, I am interested in non-local operator of the form $A(f)(x)= \int_{\mathbb R} \tilde A(x-x') f(x')\,\mathrm d x'$ with $f$ in the Swartz space. Suppose $B$ acts on $\mathcal C^{\infty}(\mathbb R,\mathbb R)$ as: $B(f)(x)= \int_{\mathbb R} e^{-(x-x')^2/2} f(x')\,\mathrm d x'$ and has symbol $\sigma(B)(x,\xi) = e^{-\xi^2/2},\quad(x,\xi)\in\mathbb R^2$ (notice, no dependence on $x$). $\sigma(B)$ is a Hörmander symbol in the class $\mathcal S^{m}_{1,0},\; \forall\, m\in \mathbb R$. **Question**: Does $\sigma_p(B)$ exist? Is it a generic feature of non-local operator not to have a principal symbol? Can the Atiyah-Singer index formula be applied to such operators? N.B. For the notion of Hörmander symbol one can look the Wikipedia page on pseudo-differential operators.