A continuous map of 3-dimensional manifolds $f \colon M^3 \to N^3$ is called a *branched covering* if there is a link $L \subset N^3$, such that the restriction $f \colon M \setminus f^{-1}(L) \to N \setminus L$ is a covering map in the usual sense. In that case we say that $f$ is *branched along* $L$, and the *degree* of $f$ is the degree of the aforementioned restriction. A classical result by Hilden and Montesinos states that each closed orientable 3-manifold $M$ can be represented as a branched covering $M \to S^3$ over the 3-sphere branched along a knot.
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In the non-orientable case Berstein and Edmonds showed that each compact non-orientable manifold $N$ without boundary can be represented as a branched covering over $N_1=\mathbb{R}P^2 \times S^1$. Moreover, a non-orientable manifold $M$ branched covers $N_2=$ the non-trivial $S^2$-bundle over $S^1$ iff the Bockstein $\in H^2(M,\mathbb{Z})$ of its first tangent Stiefel-Whitney class is zero. The question is: is there a branched covering map from $S^3$ to at least one of the manifolds $N_1,N_2$? If this turns out to be true, then every compact 3-manifold without boundary, orientable or not, would be a branched covering of $\mathbb{R}P^2 \times S^1$.