Every connected compact Hausdorff space of weight $\aleph_1$ is the remainder $v \mathbb R \setminus \mathbb R$ of some compactification of $\mathbb R$. In particular, $[0,1]^{\aleph_1}$ is the remainder of a compactification of $\mathbb R$, and therefore $\mathbb R$ has a compactification with remainder of cardinality $2^{\aleph_1}$.

Using forcing, one can show that it is consistent to have $\mathfrak{c} < 2^{\aleph_1} < 2^{\mathfrak{c}}$. (For example, [Easton's Theorem][2] immediately implies that we may get a model where $2^{\aleph_0} = \aleph_2$, $2^{\aleph_1} = \aleph_3$, and $2^{\aleph_2} = \aleph_4$, although Easton's Theorem is a bit overkill for this.) Thus it is consistent that $\mathbb R$ has a compactification with cardinality in $[\mathfrak{c}^+,2^{\mathfrak{c}})$.

(The result about weight-$\aleph_1$ continua is proved by Dow and Hart in [this paper][1]. But the special case of $[0,1]^{\aleph_1}$ is actually much easier to prove, using the fact that $[0,1]^{\aleph_1}$ is separable. Let $\{d_1,d_2,d_3,\dots\}$ be a countable dense subset of $[0,1]^{\aleph_1}$. Map $\mathbb R$ into $[0,1] \times [0,1]^{\aleph_1}$ as follows. First map $\mathbb R$ onto the ray $[1,\infty)$, and then map $[1,\infty)$ into $[0,1] \times [0,1]^{\aleph_1}$ by linearly mapping each interval $[n,n+1]$ to the line segment connecting $(\frac{1}{n},d_n)$ to $(\frac{1}{n+1},d_{n+1})$ in $[0,1] \times [0,1]^{\aleph_1}$. This mapping embeds the ray $[1,\infty)$ in $[0,1] \times [0,1]^{\aleph_1}$, and its boundary in this embedding is precisely the set $\{0\} \times [0,1]^{\aleph_1} \approx [0,1]^{\aleph_1}$.)



  [1]: https://arxiv.org/abs/math/9805008
  [2]: https://en.wikipedia.org/wiki/Easton%27s_theorem#:~:text=The%20proof%20of%20Easton's%20theorem,2%20follows%20from%20K%C3%B6nig's%20theorem.