Concerning homogeneous polynomials: Let $P(x,y)=\sum_{j=0}^n a_j x^j y^{n-j}$ be such a polynomial, of degree $n$ such that $C:=P^{-1}(\{c\})$ is a simple closed curve for all large enough $c>0$.
If $n$ is odd, then every line through the origin will have at most one point of intersection with $C$. So, then $C$ cannot be a simple closed curve for any real $c$ -- because every line through any point interior to a simple closed curve must intersect the curve in at least two points.
It remains to consider the case when $n$ is even. Then $C$ is symmetric about the origin, and hence so is the interior of $C$. Then the centroid of the interior is the origin, and it does not depend on the level $c$.
---
Consider now the case of an elliptic polynomial
\begin{equation*}
P(z)=P(x,y)=\sum_{j=0}^n a_j x^j y^{n-j}+\sum_{j=0}^{n-1}b_j x^j y^{n-1-j}+K|z|^{n-2}
\end{equation*}
of (necessarily even) degree $n$,
where $z:=(x,y)$ and $K=O(1)$ (as $|z|\to\infty$). The ellipticity here is understood as the following condition:
\begin{equation*}
\min_{|z|=1}\sum_{j=0}^n a_j x^j y^{n-j}>0.
\end{equation*}
For any $d_*\in(0,1)$ and any real $D>0$, let $\mathcal P_{n,d_*,D}$ denote the set of all polynomials $p(x)=\sum_{j=0}^n d_j x^j$ such that $d_n\ge d_*$ and $\sum_{j=0}^n|d_j|\le D$.
Then it is not hard to see that there is a real $c_*(n,d_*,D)>0$, depending only on $n,d_*,D$, such that
for any polynomial $p(x)=\sum_{j=0}^n d_j x^j$ in $\mathcal P_{n,d_*,D}$ and for all real $c\ge c_*(n,d_*,D)$ the equation $p(x)=c$ has exactly two roots $x_\pm:=x_\pm(c)$ such that $x_-<0<x_+$ and, moreover,
\begin{equation*}
x_\pm=\pm\Big(\frac c{d_n}\Big)^{1/n}-(1+o(1))\frac{d_{n-1}}{nd_n} \tag{1}
\end{equation*}
uniformly over all polynomials $p(x)=\sum_{j=0}^n d_j x^j$ in $\mathcal P_{n,d_*,D}$ (as $c\to\infty$). This uniformity can be obtained by refining [this reasoning][1].
Moreover, without loss of generality, for all $p\in\mathcal P_{n,d_*,D}$ and real $c\ge c_*(n,d_*,D)$ we have $p'(x_\pm)\ne0$.
Let us now turn back to the elliptic polynomial $P(x,y)$. For each real $t$ consider the polynomial
\begin{equation*}
p_t(r):=P(r\cos t,r\sin t).
\end{equation*}
By the ellipticity of the polynomial $P(x,y)$, there exist $d_*\in(0,1)$ and a real $D>0$ such that $p_t\in\mathcal P_{n,d_*,D}$ for all real $t$. Take now any real $c\ge c_*(n,d_*,D)$. Then, by the paragraph right above, for each real $t$ the equation $p_t(r)=c$ has exactly two roots $r_\pm(t):=r_\pm(c;t)$ such that
$r_-(t)<0<r_+(t)$ and, moreover,
\begin{equation*}
r_\pm(t)=\pm\Big(\frac c{a(t)}\Big)^{1/n}-(1+o(1))\frac{b(t)}{na(t)}
\end{equation*}
uniformly in real $t$,
where
\begin{equation*}
a(t):=\sum_{j=0}^n a_j \cos^jt\, \sin^{n-j}t,\quad
b(t):=\sum_{j=0}^{n-1} b_j \cos^jt\, \sin^{n-1-j}t.
\end{equation*}
Moreover, $\frac{dp_t(r)}{dr}|_{r=r_\pm(t)}\ne0$. So, by the implicit function theorem, the functions $r_\pm$ are continuous (in fact, infinitely smooth).
Also, the functions $r_\pm$ are periodic with period $2\pi$, since for each real $t$ we have $p_{t+2\pi}=p_t$ and the values $r_\pm(t)$ of the the functions $r_\pm$ at $t$ are uniquely determined by the polynomial $p_t$. Furthermore, for all real $r$ and $t$ we have $p_{t+\pi}(r)=p_t(-r)$, which implies $r_+(t+\pi)=-r_-(t)$. So, letting
$$z_\pm(t):=r_\pm(t)(\cos t,\sin t),$$
we see that $z_\pm(t+2\pi)=z_\pm(t)$ and
$z_+(t)=z_-(t-\pi)$ for all real $t$. So,
the $c$-level curve of $P(x,y)$ is
\begin{align*}
C=P^{-1}(\{c\})&=\{z_+(t)\colon t\in\mathbb R\}\cup\{z_-(t)\colon t\in\mathbb R\} \\
&=\{z_+(t)\colon t\in[0,2\pi)\}\cup\{z_-(t)\colon t\in[0,2\pi)\} \\
&=\{z_+(t)\colon t\in[0,2\pi)\} \\
&=\{z_+(t)\colon t\in[0,\pi)\}\cup\{z_-(t-\pi)\colon t\in[\pi,2\pi)\} \\
&=\{z(t)\colon t\in[0,2\pi)\},
\end{align*}
where
\begin{equation*}
z(t):=R(t)(\cos t,\sin t), \quad
R(t):=
\begin{cases}
r_+(t)>0&\text{ for }t\in[0,\pi],\\
|r_-(t-\pi)|>0&\text{ for }t\in[\pi,2\pi].
\end{cases}
\end{equation*}
So, the level curve $C$ is closed and simple, and its interior is
\begin{equation*}
I(c):=\{r\,(\cos t,\sin t)\colon0\le r<R(t)\}.
\end{equation*}
The main idea for the elliptic polynomial case is to consider, for all real $c\ge c_*(n,d_*,D)$, the two opposite infinitesimal sectors of the interior $I(c)$ of the simple closed curve $C=P^{-1}(\{c\})$ between the rays $t$ and $t+dt$ and between the rays $t+\pi$ and $t+\pi+dt$, where $t$ is the polar angle in the interval $[0,\pi)$. The centroid of the union of these two sectors of $I(c)$ is at (signed) distance
\begin{equation*}
d(t)\sim \frac23\,\Big(r_+(t)\frac{|r_+(t)|^2}{|r_+(t)|^2+|r_-(t)|^2}
+r_-(t)\frac{|r_-(t)|^2}{|r_+(t)|^2+|r_-(t)|^2}\Big) \tag{2}
\end{equation*}
from the origin.
Formula (2) follows because (i) the centroid of an infinitesimal sector of radius $r>0$ between the rays $t$ and $t+dt$ is at distance $\frac23\,r$ from the origin, (ii) the area of this sector is $\frac12\,r^2\,dt$, and (iii) the centroid of the union of the two sectors is the weighted average of the centroids of the two sectors, with weights adding to $1$ and proportional to the areas of the sectors, and thus proportional to the squared radii of the sectors.
Simplifying (2), we get
\begin{equation*}
d(t)\sim-\frac{2b(t)}{na(t)}.
\end{equation*}
Averaging now over all the pairs of opposite infinitesimal sectors, we see that the centroid converges to
\begin{align*}
&-\int_0^\pi dt\,\frac{2b(t)}{na(t)}(\cos t,\sin t)\frac12\,\Big(\frac c{a(t)}\Big)^{2/n}
\Big/\int_0^\pi dt\,\frac12\,\Big(\frac c{a(t)}\Big)^{2/n} \\
&=-\int_0^\pi dt\,\frac{2b(t)}{na(t)}(\cos t,\sin t)\Big(\frac1{a(t)}\Big)^{2/n}
\Big/\int_0^\pi dt\,\Big(\frac1{a(t)}\Big)^{2/n}. \tag{3}
\end{align*}
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I have checked this result numerically for $P(x,y)=x^4 + y^4 + 3 (x - y)^4 + y^3 + x y^2 + 10 x^2$, getting the centroid $\approx(-0.182846, -0.245149)$ for $c=10^4$ and $\approx(-0.189242,-0.25)$ for the limit (as $c\to\infty$) given by (3). From the above reasoning, one can see that the distance of the centroid from its limit is $O(1/c^{1/n})$; so, the agreement in this numerical example should be considered good, better than expected.
[1]: https://math.stackexchange.com/a/3551019/96609