The name "energy" only makes physical sense for a bipartite graph, where the eigenvalues of the adjacency matrix come in pairs $\pm\lambda$. If graph represents a molecule, the adjacency matrix is the Hamiltonian in the socalled <A HREF="https://en.wikipedia.org/wiki/Tight_binding">tight-binding</A> approximation. (The vertices are atomic orbitals and the edges are nearest-neigbor bonds.) The binding energy of the molecule is the sum of all the positive eigenvalues, which equals (up to a factor of two) the sum of the absolute values. If you have intuition for which chemical bonds would destabilize a molecule, by lowering its binding energy, then the energy interpretation of $\sum|\lambda|$ can be helpful, but if you lack chemical intuition then I'm not sure that this interpretation is helpful.

When the graph is not bipartite the graph energy has no physical or chemical meaning. The sum $\sum|\lambda|$ remains a useful way to characterize a graph, see for example <A HREF="https://arxiv.org/abs/1704.00779">What is the meaning of the graph energy after all?</A> (2017).