**Definitions:** Here I present a novel conjecture using basic mathematical tools like the sum of the divisors of an integer $n$ called $\sigma(n)$, the sum of the squares of the positive divisors of n called $\sigma_2(n)$ I also use the prime-counting function which is the function counting the number of prime numbers less than or equal to some real number n. The prime-counting function is called $\pi(n)$ **Conjecture:** We introduce the following expression called $A$: $$A = \sigma_2(\pi(n) − \sigma(n + 2))$$ We focus on numbers ends with 2. I calculate $A − 1$ and so the new number ends with 1. Then I calculate the square root of this number ends with 1. When the number is an integer, it is always prime. **Example:** Let $n = 100547$, we have $A = \sigma_2(9639 − \sigma(100549)) = 8264809922$ We have $A − 1 = 8264809921$ and we calculate the square root of 8264809921 and we have $\sqrt{A−1} = \sqrt{8264809921} = 90911$ and 90911 is prime **Computing** The conjecture has been checked up to $n=2,000,000$ with the following C++ program: https://onlinegdb.com/3yNzqH_ag **Questions** 1) Is this conjecture interesting? 2) Is it possible to prove this conjecture or to find counter-example?