No. Counterexamples were first constructed by Winkelmann, as quotients of $\mathbb A^5$ by algebraic actions of $\mathbb G_{\text{a}}$. I learned this from Hanspeter Kraft's very nice article available here:
http://www.numdam.org/numdam-bin/item?id=SB_1994-1995__37__295_0.
Recently Aravind Asok and Brent Doran have been studying these kinds of examples in the setting of $\mathbb A^1$-homotopy theory, on the arxiv as math/0703137.
