The following result of Howe [https://zbmath.org/0844.20027] answers this completely: Let $\mathfrak{g}$ be a finite-dimensional simple complex Lie algebra. Then a non-trivial irreducible $\mathfrak{g}$-module $V(\lambda)$ has one-dimensional weight spaces if and only if 1. $\lambda$ is minuscule, 2. $\lambda$ is quasi-minuscule and $\mathfrak{g}$ has only one short simple root, 3. $\mathfrak{g}=C_{3}=\mathfrak{sp}_{6}$ and $\lambda=\omega_{3}$, or 4. $\mathfrak{g}=A_{l}=\mathfrak{sl}_{l+1}$ and $\lambda=m\omega_{1}$ or $\lambda=m\omega_{l}$ for some $m\in \mathbb{N}$. I was able to find this via a paper of Stembridge [https://zbmath.org/1060.17001]. As I needed exactly this property in a paper of my own, you will find definitions of minuscule and quasi-minuscule as well as references from which I drew a table of these on pages 20-21 of it (arXiv:0409359, https://arxiv.org/abs/math/0409359). They are as follows, taken from [https://zbmath.org/0957.17006] by Plotkin--Semenov--Vavilov: Non-zero minuscule weights: $\begin{array}{ll} A_{l} & \omega_{i},\ 1\leq i \leq l \\ B_{l} & \omega_{l} \\ C_{l} & \omega_{1} \\ D_{l} & \omega_{1},\ \omega_{l-1},\ \omega_{l} \\ E_{6} & \omega_{1},\ \omega_{6} \\ E_{7} & \omega_{7} \end{array} $ Quasi-minuscule weights: $ \begin{array}{ll} \begin{array}[t]{ll} A_{l} & [1,0,0,\ldots,0,1]\ (\mbox{adjoint}) \\ B_{l} & \omega_{1} \\ C_{l} & \omega_{2} \\ D_{l} & \omega_{2} \\ E_{6} & \omega_{2} \\ E_{7} & \omega_{1} \\ E_{8} & \omega_{8} \\ F_{4} & \omega_{4} \\ G_{2} & \omega_{1} \end{array} \end{array} $