Your last inequality implies that $v(x,y):=u(x,y)-u(x,-y)\geq 0,\; y>0$,
and similarly $v(x,y)\leq 0,\; y<0$. Since $v$ is harmonic, this easily implies that $v(x,y)=cy$
for some real constant $c$. Now $w(x,y):=u(x,y)-cy/2$ will satisfy $w(x,y)=w(x,-y)$
This implies $(\partial w/\partial y)(0,y)=0$ and by Cauchy-Riemann,
the complex conjugate $w^*$ to $w$ is constant on the real line.
Since $(u+iu^*)(z)=w+iw^*(z)+ciz/2$, 
we obtain a characterization: these are exactly those entire functions whose imaginary part is of the form $a+bx$  on the real line, where $a$ and $c$ are real constants. (And your original inequality is
in fact always equality).