This is surely not the most direct answer. But $\mathrm{Out}(\Pi_{g,1}) \cong \mathrm{Out}(F_{2g})$ surjects onto $\mathrm{GL}(2g,\mathbf Z)$, and the image of $\Gamma_{g,1}$ lands in $\mathrm{Sp}(2g,\mathbf Z)$. So the index is infinite for $g \geq 2$.