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Andy Putman
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I don't know about dimension 4, but for high dimensions this is a well-known open problem. I don't think much progress has been made on it for a while. I recommend Ranicki's lecture notes from Siebenmann's retirement conference for a good summary about what is known about this and related problems: http://www.maths.ed.ac.uk/~aar/slides/orsay.pdf

EDIT : Hot off the press is a paper of Manolescu claiming to disprove the conjecture of Galewski-Stern and construct manifolds in all dimensions $\geq 5$ which are not homeomorphic to simplicial complexes.

Andy Putman
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