In order to obtain an explicit description of the diffeomorphism, one can use the following argument.
Take $B=\mathbb{C}^{n-1}$, with coordinates $t_1, \ldots, t_{n-1}$, and consider the complex space $\mathcal{X}$ obtained glueing $\mathbb{P}^1 \times \mathbb{C} \times B$ with $\mathbb{P}^1 \times \mathbb{C} \times B$ by the identification of
$(y_0, y_1, z, t_1, \ldots, t_{n-1})$ with $(y_0', y_1', z',t_1, \ldots, t_{n-1})$
if
$z'=z^{-1}, \quad y_1'=y_1z^{-n}, \quad y_0'=y_0+y_1 \sum_{i=1}^{n-1}t_iz^{-i}$.
Let us denote by $\pi \colon \mathcal{X} \to B$ the family obtained in this way.
Let now $T_k \subset B$ be the determinantal locus given by rank $M \leq k$, where $M$ is the matrix
\begin{bmatrix} t_1 & \ldots & t_{k+1} \cr t_2 & \ldots & t_{k+2} \cr \cdot & \cdot & \cdot \cr \cdot & \cdot & \cdot \cr \cdot & \cdot & \cdot \cr t_{n-k-1} & \ldots & t_{n-1} \end{bmatrix}
Then, if $t \in T_k - T_{k-1}$ we have $X_t :=\pi^{-1}(t) \cong \mathbb{F}_{n-2k}$.
By using Ehresmann theorem, one concludes that
$F_n$ is diffeomorphic to $F_{n-2k}$.
Geometrically speaking, we are considering all the rank $2$ vector bundles $V$ which fit into the short exact sequence
$0 \to \mathcal{O}_{\mathbb{P}^1} \to V_n \to \mathcal{O}_{\mathbb{P}^1}(n) \to 0$.
They are classified by $H^1(\mathbb{P}^1, \mathcal{O}(-n)) \cong \mathbb{C}^{n-1}$, and we consider the family of ruled surfaces $\mathbb{P}(V_n)$, thus obtained, as a deformation of $\mathbb{F}_n = \mathbb{P}(\mathcal{O} \oplus \mathcal{O}(n)$.
This argument shows that even Hirzebruch surfaces are diffeomorphic to $S^2 \times S^2$, whereas odd Hirzebruch surfaces are diffeomorphic to $\mathbb{CP}^2 \sharp \overline{\mathbb{CP}^2}$.
The uniqueness of the symplectic structrure in each case is a more difficult story, and was proven by Lalonde and McDuff [J-curves and the classification of rational and ruled symplectic 4-manifolds, Contact and Symplectic Geometry (Cambridge, 1994)].