Let $X$ be a connected CW complex. One can ask to what extent $H_\ast(X)$ determines $\pi_1(X)$. For example, it determines its abelianization, because the Hurewicz Theorem implies that $H_1(X)$ is isomorphic to the abelianization of $\pi_1(X)$.
I'm thinking about invariants of 2-knots which can be extracted from have to do with the second homology of (covers of) their complements, and I'm therefore very much interested in the answer to the following question:

What part of the fundamental group is detected by $H_2(X)$?

In particular, is there an obvious map from $H_2(X)$ (or from part of it) into $\pi_1(X)$?
Where in the derived series of $\pi_1(X)$ would the image of $H_2(X)$ live?