Y_i are independent random variables following a normal law of mean m_i = Ax_i + B and variance V. Let's take a sample y_i ~ Y_i. I determine a and b, the weigthed least squares coefficients with weights w_i of sum 1. I am interested in an unbiased estimator of variance V. sum w_i (y_i - a x_i - b)² is obviously biased but I don't manage to get anywhere close to a simple expression for an unbiased eatimate (In the case of the constant fit, it's fairly easier,see [https://mathoverflow.net/questions/11803/unbiased-estimate-of-the-variance-of-a-weighted-mean][1].) Any ideas or references? EDIT: for the unweighted regression, it's quite standard and a factor n / (n - 2) is applied. But it won't work with weights (hint: take w_1 = 0.) [1]: https://mathoverflow.net/questions/11803/unbiased-estimate-of-the-variance-of-a-weighted-mean