One more motivated by recent questions of Zhi-Wei Sun.
Let $S_n$ be the group of permutations of $\{1,2,\ldots, n\}$.
Is it true that, for every $n \ge 8$, there is at least one even permutation $\pi \in S_n$ and at least one odd permutation $\tau \in S_n$ with $$\sum_{k=1}^n \frac{1}{k \, \pi(k)} = \sum_{k=1}^n \frac{1}{k \, \tau(k)} = 1?$$
One case for each $n$ is not hard; I made it a math.stackexchange question that was successfully answered in 12 minutes. Hopefully the other case is more interesting.
Clarification: As per the MSE question referenced above and Zhi-Wei's comment, the $n$-cycle $(1,2, \dots, n) \in S_n$ satisfies the sum condition. An $n$-cycle is an odd permutation for even $n$ and an even permutation for odd $n$.
Here are the remaining parts of the conjecture.
a. For $n$ even and $n \ge 8$, there is an even $\pi \in S_n$ satisfying $\sum_{k=1}^n \frac{1}{k \, \pi(k)} = 1$.
b. For $n$ odd and $n \ge 9$, there is an odd $\tau \in S_n$ satisfying $\sum_{k=1}^n \frac{1}{k \, \tau(k)} = 1$.
Here are the numbers of even and odd permutations satisfying the sum condition for small $n$.
\begin{array}{c|rr} n\backslash \text{sgn} & +1 & -1 \\ \hline 1 & 1 & 0 \\ 2 & 0 & 1 \\ 3 & 2 & 0 \\ 4 & 0 & 2 \\ 5 & 4 & 0 \\ 6 & 0 & 2 \\ 7 & 4 & 0\\ 8 & 6 & 4\\ 9 & 12 & 24\\ 10 & 90 & 88 \end{array}
One of the first ``interesting'' permutations is the even permutation (in cycle notation) $(1,2,5,8,7,6)(3,4) \in S_8$ which gives \begin{align*} \frac{1}{1\cdot2} + \frac{1}{2\cdot5}+ \frac{1}{3\cdot4}+ \frac{1}{4\cdot3}+ \frac{1}{5\cdot8}+ \frac{1}{6\cdot1}+ \frac{1}{7\cdot6}+ \frac{1}{8\cdot7}\\ = \frac{1}{2} + \frac{1}{10}+ \frac{1}{12}+ \frac{1}{12}+ \frac{1}{40}+ \frac{1}{6}+ \frac{1}{42}+ \frac{1}{56}=1. \end{align*} Not coincidentally, $n=8$ is the smallest value for which there are non-$n$-cycle permutations that satisfy the sum condition.