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Boundary conditions.

The map $(-\Delta + 1)^{-\frac{1}{2}}: L^p (\Omega) \to W^{1, p}_0 (\Omega)$ is a linear bijection when $\Omega$ is smooth and $1 < p < +\infty$, where $\Delta$ is the Laplacian with Dirichlet boundary conditions.

When $\Omega=\mathbb{R}^d$, this operator correspond to the convolution with the Bessel kernel of order $1$.