The statement is false for $n= 2$, as I'll show, with respect to both distances you are considering on $G(n,B(H))$ (this easily implies that it is also false for any $n>2$; on the other hand for $n=1$ the statement is true according to your definition of Fredholm subspace, as it reduces to the fact that Fredholm operators are an open subset of $B(H)$. )
Let $S$ be the injective shift operator on $\ell^2$. Recall that for any $\lambda\in \mathbb{C}$ the operator $S-\lambda$ is injective and Fredholm of index $-1$ if $|\lambda|<1$, it is not Fredholm if $|\lambda|=1$, and it is invertible if $|\lambda|>1$. It will be of use a countable direct sum of operators $\lambda_j S$; to do it more nicely, we can realize it on a suitable Hilbert decomposition of $\ell^2$ into countably many infinite dimensional subspaces.
So let $\alpha:=(\alpha_k)_{k\ge1}$ be a bounded sequence of complex numbers. Consider the bounded operator $L^\alpha$ on $H:=\ell^2(\mathbb{Z}_+)$ defined on the standard orthonormal bases $(e_k)_{k\ge1}$ by $$L^\alpha e_k = \alpha_k e_{2k}\ .$$ Assume further that the sequence $\alpha$ satisfies $\alpha_{2k}=\alpha_k$ for all $k\ge 1$. Then $H$ splits in a Hilbert sum of a countable family of $L^\alpha$-invariant subspaces, $H=\bigoplus_{j\in\mathbb{N}} H_j $, with $H_j:=\operatorname {Span}(e_{(2j+1)2^n}: n\ge0)$. Moreover, for any $j\ge0$ the operator $L^\alpha_{\ |H_j}$ on $H_j$ is unitary equivalent to $\alpha_{2j+1}S$ on $\ell^2$. Thus for any $\lambda\in\mathbb{C}$ the operator $L^\alpha-\lambda I$ is unitary equivalent to the direct sum $\bigoplus_{j\in\mathbb{N}} \big(\alpha_{2j+1}S-\lambda\big)$. The $j$-th component $\alpha_{2j+1}S-\lambda$ is either non-Fredholm, or injective Fredholm of index $-1$, or invertible according whether $|\lambda|=|\alpha_{2j+1}|$, $|\lambda|<|\alpha_{2j+1}|$, respectively $|\lambda|>|\alpha_{2j+1}|$, in which case $\big\|\big(\alpha_{2j+1}S-\lambda\big)^{-1}\big\|\le\frac{1}{|\lambda|-|\alpha_{2j+1}|} .$
Therefore the operator $L^\alpha-\lambda I$ is Fredholm of index $$\mathrm{ind}(L^\alpha-\lambda I)=-\mathrm{card} \{j\ge0\ : |\alpha_{2j+1}| > |\lambda| \}\ , $$
provided $|\alpha_{2j+1}|$ is bounded away from $|\lambda| $ and $|\alpha_{2j+1}|<|\lambda| $ for all but finitely many $j$, say $m$: indeed, in this case $L^\alpha-\lambda I$ is the direct sum of a bounded family of invertible operators whose inverses have bounded norms, plus $m$ Fredholm operators of index $-1$, thus the direct sum of an invertible operator and a Fredholm operator of index $-m$.
As a consequence, the $2$-dimensional subspace $V^\alpha$ generated by the operator $L^\alpha$ and the identity $I$ is a Fredholm subspace according to your definition, if e.g. the sequence $|\alpha_{2j+1}|$ is eventually constant, and it is not, if e.g. it is strictly decreasing. Indeed, in the former case the index of Fredholm operators in $V^\alpha$ can only assume finitely many values, while in the latter case $V^\alpha$ possesses Fredholm operators of any negative index. On the other hand, for bounded sequences $\alpha$ and $\beta$ one has $\|L^\alpha-L^\beta\|\le |\alpha-\beta|_\infty$ for the operator norm, so that $V^\alpha$ depends continuously from $\alpha $ (and a fortiori, if you adopt the inner product norm deduced from $\langle\ ,\ \rangle$, which is weaker). Since an eventually constant sequence is arbitrarily close to strictly decreasing sequences in the $\ell_\infty$ norm, we conclude that Fredholm subspaces of $G(2,B(H))$ are not an open subset.