Let $A(k,n)$ be the set of $\{0,1\}$ matrices of order $n$ with all their line sums equal to $k$.
Conjecture number 5 on the list from Minc's book, attributed to Ryser, says that if $A(k,n)$ contains incidence matrices of symmetric $(n,k,\lambda)$-designs, then the minimum permanent on $A(k,n)$ is attained at one of theses incidence matrices.
It's also number 8 on Zhan's recent list of open problems in matrix theory. As one can see there, it has been verified by Wanless up to $n=12$ but not beyond.
I wonder if, given the recent progress on permanents, there is more known now about this conjecture?