At least in the case of complex algebraic varieties one can give a nice topological interpretation of the normality condition. Let us consider $V$ a complex algebraic variety, then its complex points $V(\mathbb{C})$ has the structure of a stratified pseudomanifold.
Let me recall that a stratified pseudomanifold $X$ is a filtered topological space $$X_0\subset\ldots \subset X_n$$ such that each stratum, i.e. a connected component of $X_i-X_{i-1}$ is a manifold of dimension $i$ and such that $X_{n-1}=X_{n-2}$ and such that the regular part $X_n-X_{n-2}$ is dense in $X$. Together with a local condition: the existence of conical charts.
Thus $V(\mathbb{C})$ comes equipped with such a geometric structure. In the setting of stratified pseudomanifold one has a notion of normal pseudomanifold and normalization is a fundamental concept in intersection homology. A pseudomanifold $X$ of dimension $n$ is said to be normal if for every point $x\in X$ the local homology group $H_n(X,X-x,\mathbb{Z})$ is isomorphic to $\mathbb{Z}$. Notice that a homological manifold is normal. Using Zariski’s Main Theorem, one can prove that a normal complex algebraic variety is a normal pseudomanifold.
If you consider a triangulation $T$ of $X$ ($dim(X)=n$) then you can also prove that $X$ is normal if and only if the link of eack simplex in the $n-2$-skeleton of $T$ is connected. This is proved in Goresky, MacPherson "Intersection Homology theory" (Topology Vol. 19 (1980)). In this paper the authors also explains how to build normalization topologically and how topological normalization satisfies a universal property. In the case of $V(\mathbb{C})$ its topological normalization in the sense of Goresky-MacPherson is homeomorphic to $V'(\mathbb{C})$ where $V'$ is the algebraic normalization of $V$.
Thus topologically normality corresponds to the connectivity of the links, the link of a point in an $n$-dimensional manifold being a $n-1$ sphere we see that topological normalization is the very first step to desingularization of stratified pseudomanifolds.