For integer $1\le k\le n$, let ${\overline H}_n^k$ denote the complement of the $k$-th power of the Hamming graph on the vertex set ${\mathbb F}_2^n$; that is, two vectors from ${\mathbb F}_2^n$ are adjacent in ${\overline H}_n^k$ whenever they differ in $k+1$ coordinates at least. What is the chromatic number of this graph?

Assuming for simplicity that $k$ is even, the Kneser graph $G_{n,k/2+1}$ is a subgraph of ${\overline H}_n^k$. As a result, $$ \chi({\overline H}_n^k) \ge \chi(G_{n,k/2+1})=n-k. $$ Improving upon this estimate (for $k$ close to $n$) would yield an improved bound for the number of Hamming spheres, needed to cover the whole space ${\mathbb F}_2^n$ (see this MO post).